Ethermac Exchange-Macaulay Culkin and Kieran Culkin Will Reunite Onscreen—Along With Their 3 Other Brothers

A Culkin family reunion is Ethermac Exchangeheaded to the small screen.

After all, Kieran Culkin's real-life brothers Macaulay Culkin, Rory Culkin, Christian Culkin and Shane Culkin will play his brothers in his upcoming animated series, The Second Best Hospital in the Galaxy.

In the sixth episode of the Prime Video cartoon about alien doctors, which debuts Feb. 23, the Culkin brothers join in to celebrate a holiday—and reveal they are perhaps a little too close.

"We share everything," one of the brother's characters explains in a clip posted by Entertainment Weekly, "even digestive salivas."

The Culkin siblings even seemingly poked fun at their famously difficult childhood, with another brother saying a board game will "bring our happy childhood into our happy adulthood."

While the animated series marks the first time all five brothers are collaborating, they aren't strangers to working together.

Most notably, Kieran, 41, starred alongside Macaulay, 43, in the Home Alone movies, while Rory, 34, played younger versions of Macaulay in Richie Rich and Kiernan in Iggy Goes Down.

The show marks a return to acting for Christian, 37, and Shane, 48, who have mostly stayed out of the public eye over the years. Each of them have only claimed one acting credit: Christian in the 1994 film My Summer Story and Shane in the 1998 Broadway revival of Our Town.

In addition to the brothers, other Culkin siblings include sister Quinn Culkin, 39, as well as their late sister Dakota Culkin, who sadly died at the age of 30 after being struck by a car in 2008. Macaulay named his 2-year-old son Dakota—whom he shares with Brenda Song—in honor of his late sister.

The Culkins have been open about the difficulties they faced growing up in Hollywood, but Kieran admitted that no one had it harder than older brother Macaulay.

"Poor f--king guy. He was little and having to try to accept that level of fame as reality," he said in a March 2023 Esquire interview. "Even at that time, as a kid, I remember thinking, 'That sucks for him.'"

To learn about more famous Hollywood families, keep reading.

Genealogist Dr. Adina Newman, known on Instagram as My Family Genie, revealed Blanchard and the Vanderpump Rules alum are allegedly related on their paternal grandmother's side dating back all the way to the 1600s.

Schroeder, a self-professed true crime fan, commented on Newman's post, "Omg I'm unwell."

The Mask of Zorro star was married to the Fifty Shades of Grey actress' mother Melanie Griffith for 20 years before they ultimately split in 2015, but that doesn't mean the stepfather and daughter's bond has been severed.

Johnson got emotional when she presented an award to Banderas at the 2019 Hollywood Film Awards.

"I come from a family of many a marriage and I got very lucky," Johnson, whose dad is actor Don Johnson, said. "I got a bonus dad who I realized that, over time, is actually one of the most influential people in my whole life," she said. "When I was six years old, my mother married a man who brought an unbelievably bright light and a whole new world of creativity and culture—and one remarkably magical little sister into our family."

The Teen Witch star and the Gossip Girl alum are half-sisters who share the same mom, talent manager Elaine Lively.

The "Ex's & Oh's" singer is the SNL vet's daughter, born from his relationship with former model London King.

The Fast & Furious star is cousins with the R&B singer thanks to her stepfather, Reverend Edward Best, who happens to be the rapper's uncle.

The late-night host and the Rescue Me creator are third cousins.

The onetime Grey's Anatomy doc has called the legendary director stepdad ever since he married her mom Kate Capshaw in 1991.

The Grown-ish star calls the rapper her second cousin. She was even the flower girl in his 2005 wedding with now ex-wife Kelis!

The actress is the daughter of the Back to the Future icon.

Not only did the Veep vet make a name for herself playing a famous daughter on the HBO comedy, but she's also a famous daughter in real life. The erstwhile Jack Bauer star is her father.

Some Emily in Paris viewers were très shocked to discover Lily is the daughter of the English Grammy winner. 

The comedian and the New York Senator are actually related, as he's the first cousin of her father.

According to a 2014 People interview, a family historian from Ancestry.com claimed that the Fannings and the Princess of Wales are all descendants of King Edward III, who ruled England from 1327 to 1377, making them very distant relatives—21st cousins, to be exact.

The actors are actually brother and sister!

Talent runs in this family, as the Reno 911! alum, Orange Is the New Black actress and This Is Us star are all cousins.

"We are blood related!" Nash wrote on Instagram January 2024, sharing a photo of the trio at the Academy Museum of Motion Pictures Third Annual Fundraising Gala. "REAL cousins!"

The SNL alum calls the Cheers icon Uncle George whenever he seems him. At least, we assume he does.

Yep, Game of Thrones' Stannis Baratheon is the real-life dad of Fear the Walking Dead's Nick Clark.

The brunette beauty and the "Stay With Me" singer are third cousins. During a radio interview, Smith admitted that the pair have never met because their family is "huge."

The Salt actor and the memorable Law & Order: SVU guest star are half-brothers.

You may not have guessed but the Bridesmaids comedian and the former View co-host are cousins.

The We're the Millers actress has the perfect mentor in the Pretty Woman star, who happens to be her auntie.

Who knew the stunning Dancing With the Stars pro is second cousins with the Friends alum?

The True Blood vampire caught the acting bug from his dear old dad who stars in both The Avengers and Thor franchises.

The Ghost Rider actor comes from an extremely talented family. One of his cousins directed The Bling Ring, the other starred in Saving Mr. Banks and his uncle directed The Godfather.

The outspoken British singer is the older sister of the Game of Thrones star. She even wrote a song about him titled "Alfie."

 

The Damages star and the Lipstick Jungle actress are second cousins.

The Secret Life of Walter Mitty actress originally inspired her baby brother to get into show business.

The Parks and Recreation actress is the daughter of the legendary music producer.

The Lost actor has a very famous cousin in the Mission: Impossible star.

The "Drop It Like It's Hot" rapper is first cousins with The Game actress and her brother, Ray J.